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Indian Journal of Dental Research :... 2021Basal cell carcinoma is the most common cutaneous malignancy which is exclusively observed on sun exposed and hair bearing areas of the face.
INTRODUCTION
Basal cell carcinoma is the most common cutaneous malignancy which is exclusively observed on sun exposed and hair bearing areas of the face.
DIAGNOSIS
We report two rare cases of basal cell carcinoma, which presented as a diagnostic challenge because of rare histopathology.
FINDINGS
Both cases showed pigmentation, while one case resembled adenoid cystic carcinoma because of the glandular and ductal pattern of basaloid cells.
RESULT
We present these cases because of rare histopathologic presentation.
Topics: Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Humans; Skin Neoplasms
PubMed: 35229784
DOI: 10.4103/ijdr.IJDR_227_19 -
Journal of Medical Case Reports Oct 2021Basal cell carcinoma is the most common nonmelanotic skin cancer. It has variable clinical and histological subtypes that vary in their aggressiveness and liability to... (Review)
Review
INTRODUCTION
Basal cell carcinoma is the most common nonmelanotic skin cancer. It has variable clinical and histological subtypes that vary in their aggressiveness and liability to recurrence and metastasis. Chronic ultraviolet radiation exposure is considered to be the main risk factor for developing basal cell carcinoma; therefore, it typically arises on sun-exposed skin, mainly the head and neck.
CASE PRESENTATION
We present the case of a 55-year-old Caucasian male who presented with a lesion on the scrotum for 2 years. The lesion was clinically presumed benign and initially treated with curettage. Microscopic examination revealed an incompletely resected micronodular basal cell carcinoma with sebaceous differentiation. Therefore, a second excisional biopsy was performed to completely excise the incidentally discovered malignant tumor.
CONCLUSION
We report the first case of micronodular basal cell carcinoma arising on the scrotum. The goal of our article is to draw clinicians' attention to the possible involvement of unexposed skin with basal cell carcinoma, and we highlight the importance of accurate diagnosis and prompt treatment due to the aggressive nature of micronodular basal cell carcinoma.
Topics: Carcinoma, Basal Cell; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Scrotum; Skin Neoplasms; Ultraviolet Rays
PubMed: 34656174
DOI: 10.1186/s13256-021-03124-6 -
Dermatology (Basel, Switzerland) 2023Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer in Switzerland and worldwide. Most BCCs can be treated in a curative setting. However, patients can... (Review)
Review
Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer in Switzerland and worldwide. Most BCCs can be treated in a curative setting. However, patients can develop locally destructive and, rarely, metastatic tumors that require a different treatment approach. The clinical subtype of individual lesions provides prognostic information and influences management decisions. Surgical excision, topical therapies, and radiotherapy are highly effective in the majority of subtypes as well as in low- and high-risk diseases. For patients with low-risk diseases and superficial tumors not amenable to surgery, several nonsurgical alternatives are available. Systemic therapy is indicated for high-risk BCCs, which are not amenable to either surgery or radiotherapy. Hedgehog pathway inhibitors (HHI) are currently approved. Other therapeutic options such as immune checkpoint inhibitors show promising results in clinical trials. This first version of Swiss recommendations for diagnosis and management of BCC was prepared through extensive literature review and an advisory board consensus of expert dermatologists and oncologists in Switzerland. The present guidelines recommend therapies based on a multidisciplinary team approach and rate of recurrence for individual lesions. Based on the risk of recurrence, two distinct groups have been identified: low-risk (easy-to-treat) and high-risk (difficult-to-treat) tumors. Based on these classifications, evidence-based recommendations of available therapies are presented herein.
Topics: Humans; Antineoplastic Agents; Carcinoma, Basal Cell; Hedgehog Proteins; Skin Neoplasms; Switzerland
PubMed: 36137524
DOI: 10.1159/000526478 -
The British Journal of Dermatology Jun 2005Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell carcinoma (BCC). The... (Review)
Review
Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell carcinoma (BCC). The significant progress that has been made warrants a comprehensive review of the molecular and cellular pathology of BCC. The items addressed include environmental and genetic risk factors, the biology of the putative precursor cell(s), and the contribution of aberrations in processes such as apoptosis, cell proliferation, differentiation and signalling to carcinogenesis. Furthermore, established and novel treatment modalities are discussed with particular attention to future biological approaches.
Topics: Apoptosis; Carcinoma, Basal Cell; Cell Differentiation; Cell Proliferation; Epidermis; Genetic Predisposition to Disease; Humans; Immunosuppression Therapy; Immunotherapy; Risk Factors; Skin Neoplasms; Ultraviolet Rays; Virus Diseases
PubMed: 15948971
DOI: 10.1111/j.1365-2133.2005.06587.x -
Journal of B.U.ON. : Official Journal... 2019To investigate the relationship between the expression level of miR-34a in the serum of basal cell carcinoma patients and the clinical prognosis.
PURPOSE
To investigate the relationship between the expression level of miR-34a in the serum of basal cell carcinoma patients and the clinical prognosis.
METHODS
Eighty-six patients with basal cell carcinoma who underwent surgery from July 2011 to July 2013 were enrolled in the experimental group, and 85 healthy volunteers were selected from the physical examination department of Henan Province Luoyang Orthopedic Traumatological Hospital to serve as control group. Real-time PCR was used to detect the expression of miR-34a in the serum of the study subjects. Patients were divided into high- and low-expression groups according to the median expression levels of miR-34a. Survival analysis was performed using Kaplan-Meier method.
RESULTS
Serum miR-34a levels were significantly lower in basal cell carcinoma patients than in healthy volunteers (p<0.001). The expression level of miR-34a was correlated with tumor cell diameter, lymph node metastasis and histological types of basal cell carcinoma (p<0.001). The expression of miR-34a was not associated with patients' age, primary site and the pathological type of tumors (p>0.05). Median progression-free survival of patients with high expression and low expression was 37 and 20 months, respectively (p<0.05). Median overall survival time was 44 and 31.5 months, respectively (p<0.05). Overall survival rate was 76.74% in the high expression group, significantly higher (p<0.05) compared with the low expression group. miR-34a was significantly underexpressed in basal cell carcinoma, and the prognosis of basal cell carcinoma patients with low expression levels of miR-34a was poor.
CONCLUSION
MiR-34a is expected to be an effective biomarker for basal cell carcinoma assessment and prognosis.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Female; Humans; Male; MicroRNAs; Middle Aged; Prognosis; Young Adult
PubMed: 31424691
DOI: No ID Found -
BMJ (Clinical Research Ed.) Oct 2003The authors of this review aim to provide a comprehensive overview of basal cell carcinoma, concentrating in particular on incidence, risk factors, molecular genetics,... (Review)
Review
The authors of this review aim to provide a comprehensive overview of basal cell carcinoma, concentrating in particular on incidence, risk factors, molecular genetics, clinical features, and treatment
Topics: Carcinoma, Basal Cell; Global Health; Humans; Incidence; Phenotype; Risk Factors; Skin Neoplasms
PubMed: 14525881
DOI: 10.1136/bmj.327.7418.794 -
Tissue & Cell Oct 2022Suprabasin is a newly discovered protein linked to various human diseases including cancer. It may does have an effect on the development and expression of some...
INTRODUCTION
Suprabasin is a newly discovered protein linked to various human diseases including cancer. It may does have an effect on the development and expression of some non-melanoma skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC is the most common non-melanoma skin cancers worldwide, while SCC comes as the second in terms of prevalence. In certain cases, it is very important to distinguish between these two carcinomas from each other and from normal skin samples. This study was aimed at investigating the characteristics of suprabasin expression in squamous cell carcinoma and basal cell carcinoma and whether it can be used as a biomarker.
MATERIALS AND METHODS
Thirty control, ninety SCC and thirty BCC cases obtained from the archives of the Department of Pathology, Faculty of Medicine, Fırat University, were examined by immunohistochemical staining for suprabasin.
RESULTS
Increased suprabasin expression was observed in tumour tissues and normal skin samples in SCC. As the grade increased in SCC, suprabasin expression decreased. No suprabasin expression was observed in the lesion area in BCC.
CONCLUSION
Suprabasin can be reported as a biomarker for SCC and used to differentiate SCC from BCC. Expression of suprabasin in SCC can be used to determine grade. Absence of suprabasin expression in BCC can be used for differential diagnosis.
Topics: Biomarkers; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Skin Neoplasms
PubMed: 35930991
DOI: 10.1016/j.tice.2022.101875 -
Anais Brasileiros de Dermatologia 2015Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide...
Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.
Topics: Carcinoma, Basal Cell; Cell Nucleus; Chromatin; Cross-Sectional Studies; Epithelium; Humans; Skin Neoplasms; Statistics, Nonparametric; Tumor Burden
PubMed: 26734870
DOI: 10.1590/abd1806-4841.20154076 -
Skin Research and Technology : Official... May 2022The similar visual appearance of high-risk basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) may cause confusion for diagnosis. High-frequency...
BACKGROUND
The similar visual appearance of high-risk basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) may cause confusion for diagnosis. High-frequency ultrasound (HFUS) may provide additional intralesional information and thus help to distinguish them.
METHOD
In this retrospective study, we analyzed the clinical characteristics, HFUS grayscale, and color Doppler flow imaging (CDFI) features of pathologically confirmed high-risk BCC and cSCC lesions (n = 65 vs n = 68). Subsequently, discrimination models based on the significant HFUS features were established.
RESULTS
Between high-risk BCC and cSCC lesions, the HFUS grayscale features of the lesion size (10.0 mm vs 17.4 mm), thickness (3.1 mm vs 5.9 mm), internal hyperechoic spots (80.0% vs 23.5%), and posterior acoustic shadowing (16.9% vs 66.2%) were statistically different (all p < 0.001). As for the CDFI features, high-risk BCC lesions mainly appeared as pattern II (47.7%), while cSCC lesions mainly appeared as pattern III (66.2%). Based on the above five features, an optimal discrimination model was established with a sensitivity of 91.2%, a specificity of 87.7%, and an accuracy of 89.5%.
CONCLUSION
HFUS features, including size, thickness, internal hyperechoic spots, posterior acoustic shadowing, and Doppler vascularity pattern, are useful for differential diagnosis between high-risk BCC and cSCC.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Retrospective Studies; Skin Neoplasms; Ultrasonography
PubMed: 34923684
DOI: 10.1111/srt.13121 -
Ugeskrift For Laeger May 2016Basal cell carcinoma (BCC) is the most common type of cancer in humans. The lifetime risk of developing BCC is 30%. The scope of the treatment is total eradication of... (Review)
Review
Basal cell carcinoma (BCC) is the most common type of cancer in humans. The lifetime risk of developing BCC is 30%. The scope of the treatment is total eradication of the tumour followed by preservation of functionality and optimal cosmetic results. The risk of recurrence after treatment is highest in the tumours with aggressive growth patterns, in tumours located in the facial H-zone and in recurrent tumours. The optimal treatment of high-risk BCCs is surgical excision or radiotherapy. Low-risk tumours may be treated with cryotherapy, curettage, photodynamic therapy or topical agents.
Topics: Carcinoma, Basal Cell; Humans; Neoplasm Metastasis; Risk Assessment; Skin Neoplasms
PubMed: 27189106
DOI: No ID Found